Request epinephrine auto-injector prescription renewal from an online doctor or NP. For EpiPen prescriptions like EpiPen generic, Adrenaclick, Auvi-Q, Symjepi. Pay a flat fee - insurance not accepted for visits.
Request epinephrine auto-injector prescription renewal from an online doctor or NP. For EpiPen prescriptions like EpiPen generic, Adrenaclick, Auvi-Q, Symjepi. Pay a flat fee - insurance not accepted for visits. 4.9 47
Ages 18-64
This is right for you if
You’ve been prescribed an epinephrine auto-injector (EpiPen) in the past
You’re at risk of anaphylaxis

Did you know?

• Up to 51% of anaphylactic reactions happen at home
• A mild allergic reaction doesn’t predict the severity of future allergic reactions
• According to one survey, 60% of U.S. adults who experience anaphylaxis don’t have epinephrine available

What's included

Personalized treatment plans may include a prescription renewal for epinephrine auto-injectors. This prescription can be used at a pharmacy of your choice for EpiPen refills. You can message your online doctor or nurse practitioner with follow-up questions for 14 days after you get your treatment plan.
Concerned about more than your EpiPen refill?
Commonly prescribed epinephrine auto-injectors
  • EpiPen generic
  • AUVI-q
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This chart is for informational purposes only. Your clinician will determine treatment plans, prescriptions, and number of refills (if any) based on your symptoms and health history.
Epinephrine auto-injector renewal isn’t available at Alpha or SteadyMD at this time. Curai Health and Wheel have licensed clinicians (like MDs, DOs, and NPs). At Curai Health, the typical prescription is 1 pack (2 auto-injectors) and 1 refill. Curai Health won’t prescribe Adrenaclick. At Wheel, the typical prescription is 1 pack (2 auto-injectors) and 1 refill.

What you’ll need

A photo ID, like a driver's license or passport, if we need additional identity verification
5 to 10 minutes to answer questions about your symptoms and health history

How it works

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Choose an online clinic
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Fill out an intake form
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Connect with a clinician, no appointment needed
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Get a personalized treatment plan
You can message your clinician with follow-up questions for 14 days after you get your treatment plan.
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You should know
Based on your health information, your clinician may recommend that you see a healthcare provider in person. If that happens, you won’t be charged for your visit. Amazon Clinic doesn’t accept insurance at this time, and isn’t intended for beneficiaries of government payor programs, including Medicare and Medicaid.

Frequently asked questions

What epinephrine auto-injector prescriptions can I get renewed through Amazon Clinic?
Prescription renewals for the following epinephrine auto-injectors are available through Amazon Clinic:
• Adrenaclick
• AUVI-q, which has voice instructions
• EpiPen
• EpiPen generic
• Symjepi (prefilled syringe)
The cost of an EpiPen can vary widely depending on insurance coverage, pharmacy discounts, and whether you choose generic or brand-name medication. The FDA approved generic EpiPen options in 2018, which lowered prices for many people at risk of anaphylaxis.

Please note: This information is for general reference only. Your online doctor or nurse practitioner will review your symptoms and health history to determine which (if any) anaphylaxis treatments are medically appropriate.
Who needs an EpiPen?
EpiPens are prescribed to people who are at risk of experiencing a severe and potentially fatal allergic reaction called anaphylaxis. If you've already experienced anaphylaxis and you might encounter the triggering agent again, then clinicians recommend that you keep an epinephrine auto-injector on hand. It could keep you out of the hospital, or even save your life.

If you've already experienced anaphylaxis and you don't know what triggered the allergic reaction, you also need an EpiPen in case you encounter the unknown trigger again.
What exactly does an EpiPen do?
Epinephrine, the medication in an EpiPen, is the only effective treatment for anaphylaxis. After epinephrine is injected into the thigh of someone experiencing anaphylactic shock, the medication immediately starts working to reduce their throat swelling, open their airways, and stabilize their heart function and blood pressure.

While antihistamines can treat mild allergic reactions, there's no life-saving substitute for epinephrine when multiple organ systems are involved.
What can trigger anaphylaxis?
The most common triggers of anaphylaxis are medications (like antibiotics or NSAIDs), stinging insects (like bees, wasps, or fire ants), and foods (like shellfish, peanuts, or tree nuts). But in up to 20% of cases, the trigger is unknown.

Anaphylaxis can happen quickly after exposure to the allergen, normally within one to two hours, and sometimes within minutes. It can also reoccur up to 3 days after exposure, which is why people at high risk should be monitored closely after a severe allergic event.
How do you recognize the signs of anaphylactic shock?
While mild or moderate allergic reactions only involve one organ system, usually the skin, anaphylaxis is characterized by the sudden involvement of one or more organ systems. So someone with anaphylaxis might have trouble breathing in addition to hives. We recommend that you become familiar with the full list of anaphylaxis symptoms below:
• Hives (skin rash with itchy bumps)
• Skin itching or flushing
• Difficulty breathing
• Swelling of the tongue, lips, or uvula
• Swelling or tightness in the throat
• Sudden persistent cough
• Wheezing
• Abdominal cramps or vomiting
• Low blood pressure (systolic BP lower than 90 or at least 30% lower than usual)*
*Low blood pressure can sometimes be the sole symptom of anaphylactic shock.
What types of visit can I have?
Video visits are available in all 50 states and D.C. Message-only visits are available in 34 states. To see your visit options, first choose your state.
Can I use my health insurance to pay for a visit and/or medication?
Amazon Clinic doesn't accept health insurance for visits at this time. You can submit a claim to your insurance provider for reimbursement, but we can’t guarantee they’ll reimburse you.

If you normally use insurance to pay for your medications, you can do that with medications prescribed through Amazon Clinic. Amazon Pharmacy accepts most insurance plans. For other pharmacies, please talk with your pharmacy directly about insurance coverage. The cost of medication isn’t included in the cost of your visit.
How does Amazon Clinic protect my health information?
Amazon Clinic protects your health information by strictly following the requirements of the Health Insurance Portability and Accountability Act (HIPAA). HIPAA governs what Amazon Clinic and your healthcare providers can do with your medical information, as well as your contact and payment information. Amazon Clinic doesn’t and will never sell your personal information. Learn more on our privacy page.
  1. Brown, J. C., Simons, E., & Rudders, S. A. (2020). Epinephrine in the Management of Anaphylaxis. The journal of allergy and clinical immunology. In practice, 8(4), 1186–1195. Retrieved from
  2. Pflipsen, M. C., & Vega Colon, K. M. (2020). Anaphylaxis: Recognition and Management. American family physician, 102(6), 355–362. Retrieved from
  3. Wood, R. A., Camargo, C. A., Jr, Lieberman, P., Sampson, H. A., Schwartz, L. B., Zitt, M., Collins, C., Tringale, M., Wilkinson, M., Boyle, J., & Simons, F. E. (2014). Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States. The Journal of allergy and clinical immunology, 133(2), 461–467. Retrieved from