The best medicine for sinusitis (inflammation of the sinuses) depends on what's causing the infection. Almost all sinus infections are caused by viruses, which don't respond to antibiotics. Your clinician may prescribe antibiotics for a sinus infection that's determined to be bacterial.
If you’ve had sinusitis symptoms (like sinus headache, facial pressure, and nasal congestion) for less than a week, it may be too early to tell what's causing the inflammation. Your clinician may then take a wait-and-see approach, recommending over-the-counter (OTC) treatments during this time. If your symptoms don't improve, you might be a candidate for antibiotics.