Prescription renewals for the following epinephrine auto-injectors are available through Amazon Clinic:

The cost of an EpiPen can vary widely depending on insurance coverage, pharmacy discounts, and whether you choose generic or brand-name medication. The FDA approved generic EpiPen options in 2018, which lowered prices for many people at risk of anaphylaxis.

Please note: This information is for general reference only. Your online doctor or nurse practitioner will review your symptoms and health history to determine which (if any) anaphylaxis treatments are medically appropriate.

EpiPens are prescribed to people who are at risk of experiencing a severe and potentially fatal allergic reaction called anaphylaxis. If you've already experienced anaphylaxis and you might encounter the triggering agent again, then clinicians recommend that you keep an epinephrine auto-injector on hand. It could keep you out of the hospital, or even save your life.

If you've already experienced anaphylaxis and you don't know what triggered the allergic reaction, you also need an EpiPen in case you encounter the unknown trigger again.

Epinephrine, the medication in an EpiPen, is the only effective treatment for anaphylaxis. After epinephrine is injected into the thigh of someone experiencing anaphylactic shock, the medication immediately starts working to reduce their throat swelling, open their airways, and stabilize their heart function and blood pressure.

While antihistamines can treat mild allergic reactions, there's no life-saving substitute for epinephrine when multiple organ systems are involved.

The most common triggers of anaphylaxis are medications (like antibiotics or NSAIDs), stinging insects (like bees, wasps, or fire ants), and foods (like shellfish, peanuts, or tree nuts). But in up to 20% of cases, the trigger is unknown.

Anaphylaxis can happen quickly after exposure to the allergen, normally within one to two hours, and sometimes within minutes. It can also reoccur up to 3 days after exposure, which is why people at high risk should be monitored closely after a severe allergic event.

While mild or moderate allergic reactions only involve one organ system, usually the skin, anaphylaxis is characterized by the sudden involvement of one or more organ systems. So someone with anaphylaxis might have trouble breathing in addition to hives. We recommend that you become familiar with the full list of anaphylaxis symptoms below:

*Low blood pressure can sometimes be the sole symptom of anaphylactic shock.

Video visits are available in all 50 states and D.C. Message-only visits are available in 34 states. To see your visit options, first choose your state.

Amazon Clinic doesn't accept health insurance for visits at this time. You can submit a claim to your insurance provider for reimbursement, but we can’t guarantee they’ll reimburse you.

If you normally use insurance to pay for your medications, you can do that with medications prescribed through Amazon Clinic. Amazon Pharmacy accepts most insurance plans. For other pharmacies, please talk with your pharmacy directly about insurance coverage. The cost of medication isn’t included in the cost of your visit.

Amazon Clinic protects your health information by strictly following the requirements of the Health Insurance Portability and Accountability Act (HIPAA). HIPAA governs what Amazon Clinic and your healthcare providers can do with your medical information, as well as your contact and payment information. Amazon Clinic doesn’t and will never sell your personal information. Learn more on our privacy page.