There are two main types of prescription acid reflux (GERD) medicines: histamine 2 receptor antagonists (H2RAs)—also known as H2 blockers—and proton pump inhibitors (PPIs). Both types of drug target acid production in the stomach.

If you've never tried a prescription-strength heartburn medicine before and you have mild symptoms fewer than two times a week, your clinician may prescribe an H2RA like famotidine (Pepcid AC) or nizatidine (Axid AR).

If you have severe symptoms, and/or symptoms twice a week or more, your clinician may prescribe a PPI like esomeprazole (Nexium), lansoprazole (Prevacid), or omeprazole (Prilosec, Zegerid). PPIs are stronger GERD medications than H2RAs.

If you've already tried PPIs and they haven't worked for you, then you'll need to see a trusted healthcare provider like a primary care physician (PCP) or gastroenterologist (GI) for an in-person evaluation.

Please note: This information is for general reference only. Your clinician will review your symptoms and health history to determine which (if any) heartburn treatments are medically appropriate.

Heartburn is the uncomfortable burning sensation in the chest or throat that's caused by acid reflux, when stomach contents move up instead of down. Acid reflux is also called gastroesophageal reflux. Gastroesophageal reflux disease (GERD) is a more severe form of acid reflux. You can get acid reflux treatment or uncomplicated GERD treatment through Amazon Clinic.

The main symptoms of acid reflux (GERD) are heartburn and regurgitation.

More severe symptoms of GERD include the following:

If you have any of these more severe symptoms, you'll need to see a trusted healthcare provider like a primary care physician (PCP) or gastroenterologist (GI) for further testing.

Depending on the severity of your symptoms, your clinician may recommend a step-up approach or a step-down approach for treating the symptoms of GERD.

A step-up treatment approach involves starting with a low dose of medication, then raising it until symptoms stop. For example, a clinician might prescribe a low-dose H2RA, then raise the dose, then prescribe a low-dose PPI.

A step-down approach starts with a higher dose of medication, which is then lowered as long as symptoms are still controlled. For example, a clinician might prescribe a standard PPI dose, then an H2RA.

If you have mild acid reflux (GERD) symptoms like heartburn and regurgitation less than once a week, you may get temporary relief from taking an antacid. These over-the-counter (OTC) medications can begin to work in 5 minutes and last up to an hour, but they don't cure GERD. Sodium alginate is another OTC medication that can offer short-acting acid reflux symptom relief. These medications can be used at the same time as prescription medications.

There's clinical evidence that you might be able to relieve your symptoms with the following natural remedies for acid reflux/heartburn:

Some evidence also shows a benefit in wearing looser clothing, chewing gum, not drinking alcohol or smoking, and doing abdominal breathing exercises.

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Amazon Clinic doesn't accept health insurance for visits at this time. You can submit a claim to your insurance provider for reimbursement, but we can’t guarantee they’ll reimburse you.

If you normally use insurance to pay for your medications, you can do that with medications prescribed through Amazon Clinic. Amazon Pharmacy accepts most insurance plans. For other pharmacies, please talk with your pharmacy directly about insurance coverage. The cost of medication isn’t included in the cost of your visit.

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