Prescription medications for quitting smoking are generally safe.
Rarely, nicotine patches can cause redness or irritation where applied. Changing the site can help reduce this risk.
Bupropion (Zyban, Wellbutrin) is usually well tolerated. It's not recommended if you have a seizure disorder, have uncontrolled high blood pressure, drink alcohol daily, or have heart issues (like an abnormal heart rhythm or a history of heart attacks).
Chantix is well tolerated. It's not recommended if you have a heart condition that increases your risk of heart attack.